Abstract
Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC₅₀) 0.68 μM) showed inhibitory activity on β-glucuronidase enzyme, while 3 (IC₅₀) 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology*
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Cameroon
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Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / antagonists & inhibitors*
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Ficus / chemistry*
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Glucuronidase / antagonists & inhibitors*
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Inhibitory Concentration 50
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Isoflavones / chemistry
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Isoflavones / isolation & purification*
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Isoflavones / pharmacology*
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Molecular Structure
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / enzymology*
Substances
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Antimalarials
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Isoflavones
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mucusisoflavone A
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mucusisoflavone B
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mucusisoflavone C
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Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
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Glucuronidase